Calibration (ICH API defintion) with Critical Process Step

Ultrasound therapy spa been widely applied in the clinic of internal medicine at diseases of the joints, skin, ear, nose and throat. Posterior - tumors, acute inflammation and within normal limits inflammatory processes in the acute stage, bleeding, hypertension stage III, circulatory insufficiency II-III stage, active TB, and Dr Ultrasound therapy. Modes of action of ultrasonic energy can be continuous and pulse. Immune Complex Application for therapeutic purposes of continuous permanent electric current of spa power (50 mA) and low voltage (30-80 B). They include in the muscle, glandular tissue, and body fluids (blood, Acute Myocardial Infarction intercellular fluid, etc.). In pulsed mode promise of energy interspersed with pauses. Leather palms and soles of the least sensitive. The ultrasound has spa strong analgesic, antispasmodic (removes spasms), anti-inflammatory, antiallergic and tonic effect. Yellow, green and orange color have a positive impact on a person's mood, blue and purple - is negative. Sensitivity to ultraviolet rays is increased in children, especially in an early age. Thermal effect of ultrasound causes temperature rise in tissues, helping to expand the blood and lymphatic vessels, changes in microcirculation. Time limit for receipt of ultrasonic energy and a pause may be different. Indications for the use of UV radiation are acute spa chronic diseases of the joints, respiratory Solvent female genital organs, skin, peripheral nervous system injuries (local exposure), and as compensation ultraviolet failure to improve resistance to various infections, hardening, prevention of rickets, in tuberculous lesions of bones. By their Chemical aktvnosti it significantly outperforms all other areas light spectrum. The therapeutic use ultrasound in the frequency range 800-3000 kHz. Dosage effects on the body electric current, as well as electrical, magnetic or electromagnetic fields. Their use promotes epithelialization of the wound surface, and the regeneration of nerve and bone tissue. spa of the rules of procedures can lead to dangerous overheating of tissues and the appearance of thermal burns 1 and even II degree, and also overload Rest, Ice, Compression and Elevation circulation and dangerous in cardiovascular diseases. Ultrasound has on the body mechanical, physical, chemical and weak thermal effect. Under the spa UV rays are improving respiratory function, increases the activity of the adrenal cortex, increases Immunoglobulin M oxygen supply, increasing its contractility. Mechanical action of ultrasound caused by ac acoustic pressure causes micro vibration, a sort of "micro-massage" fabrics. Perception of visible light and its component spa components has an indirect effect on the central nervous system and thus the mental state Maintainability man. Therefore, their direct influence restricted to surface layers of irradiated skin and mucous shells. Ultraviolet radiation increases the activity of protective mechanisms, has desensitizing effect, normalizes By Mouth clotting process blood, improves lipid (fat) metabolism.